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Brochura Institucional

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Development & Manufacturing

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Development & Manufacturing Capabilities

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Integrated CRDMO - One-stop Shop Solution

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Product Portfolio

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Value Added Medicines

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ONConcept®

Brochuras

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Oromucosal products – Market landscape and innovative technologies: A review

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Molecular structure, spectroscopy and photochemistry of alprazolam

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Hot-Melt Extrusion: a Roadmap for Product Development

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Medication adherence in older people with rheumatoid arthritis is lower according to electronic monitoring than according to pill count

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GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

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Amphiphilic well-defined degradable star block copolymers by combination of ring-opening polymerization and atom transfer radical polymerization: Synthesis and application as drug delivery carriers

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Artificial neural networks applied to quality-by-design: From formulation development to clinical outcome

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Enhanced solid-state stability of amorphous ibrutinib formulations prepared by hot-melt extrusion

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Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives

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Five-Stage Approach for a Systematic Screening and Development of Etravirine Amorphous Solid Dispersions by Hot-Melt Extrusion

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Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

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Orphan drugs: major development challenges at the clinical stage

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Critical process parameters of orodispersible films (ODFs)

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Intradermal Delivery of a Near-Infrared Photosensitizer Using Dissolving Microneedle Arrays

Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique

Retrospective Quality by Design (rQbD) applied to the optimization of orodispersible films

A first in human study using photodynamic therapy with Redaporfin in advanced head and neck cancer

Ultrafast Dynamics of Manganese(III), Manganese(II), and Free-Base Bacteriochlorin: Is There Time for Photochemistry?

The use of liposomes for the systemic delivery of RNAi therapeutics aiming at cancer treatment

Outlining critical quality attributes (CQAs) as guidance for the development of orodispersible films

Hydrophobic polymers for orodispersible films: a quality by design approach

Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination

Intravenous Single-Dose Toxicity of Redaporfin-Based Photodynamic Therapy in Rodents

Mucoadhesive oral films: The potential for unmet needs

Elimination of primary tumours and control of metastasis with rationally designed bacteriochlorin photodynamic therapy regimens

Oral films: Current status and future perspectives II — Intellectual property, technologies and market needs

Oral films: Current status and future perspectives: I — Galenical development and quality attributes

Polymeric bile acid sequestrants—Synthesis using conventional methods and new approaches based on “controlled”/living radical polymerization

Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination

Manufacturing and export provisions: Impact on the competitiveness of European pharmaceutical manufacturers and on the creation of jobs in Europe

Photodynamic Therapy Efficacy Enhanced by Dynamics: The Role of Charge Transfer and Photostability in the Selection of Photosensitizers

Modulation of Biodistribution, Pharmacokinetics, and Photosensitivity with the Delivery Vehicle of a Bacteriochlorin Photosensitizer for Photodynamic Therapy

Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform

Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer

Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment

Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges

Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: Evidence from intracellular fluorescence and increased photodynamic efficacy in vitro

Development, Characterization and In Vitro Evaluation of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations

Tissue Uptake Study and Photodynamic Therapy of Melanoma-Bearing Mice with a Nontoxic, Effective Chlorin

Biodistribution and Photodynamic Efficacy of a Water-Soluble, Stable, Halogenated Bacteriochlorin against Melanoma

Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy

Targeting non-viral vectors to tumor cells and the tumor microenvironment

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment

Synthesis and photophysical characterization of a library of photostable halogenated bacteriochlorins: an access to near infrared chemistry

New Halogenated Water-Soluble Chlorin and Bacteriochlorin as Photostable PDT Sensitizers: Synthesis, Spectroscopy, Photophysics, and in vitro Photosensitizing Efficacy

Mechanisms of Singlet-Oxygen and Superoxide-Ion Generation by Porphyrins and Bacteriochlorins and their Implications in Photodynamic Therapy

Liposomal imatinib–mitoxantrone combination: Formulation development and therapeutic evaluation in an animal model of prostate cancer

Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner

Synthesis and photophysical properties of amphiphilic halogenated bacteriochlorins: new opportunities for photodynamic therapy of cancer

Non-Viral Lipid-Based Nanoparticles for Targeted Cancer Systemic Gene Silencing

Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients

Cationic liposomes for gene delivery

Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells

On the formulation of pH-sensitive liposomes with long circulation times

Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles

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The Gloria Adherence Subproject: Problems and Randomization Mistakes

Publicações Científicas

A Blue é feita a pensar, sobretudo, nos nossos stakeholders, pretendendo refletir a evolução e as conquistas da Bluepharma. Uma publicação anual bilingue, em Português e Inglês, que está disponível em formato digital e em formato impresso.